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KMID : 1101420190510030286
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Korean Journal of Clinical Laboratory Science
2019 Volume.51 No. 3 p.286 ~ p.293
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Genetic Polymorphisms of SLC8A1 Are Associated with Hypertension and Left Ventricular Hypertrophy in the Korean Population
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Park Hye-Jeong
Kim Sung-Soo
Jin Hyun-Seok
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Abstract
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Hypertension (HTN) is one of the major chronic diseases, and HTN is defined as being in a state of continuous high blood pressure. Left ventricular hypertrophy (LVH) is a condition in which the mass of the left ventricle has increased, and HTN is a leading cause of LVH. HTN and LVH are known to be caused by the interaction of environmental factors and genetic factors. It has been reported that the polymorphisms of SLC8A1, among the genetic factors that affect high blood pressure, are related to salt sensitivity hypertension. In this study, the genetic polymorphisms of SLC8A1 were chosen based on the Korean Genome and Epidemiology data. Logistic regression analysis was then performed for HTN and LVH. Linear regression analysis was also performed for systolic blood pressure (SBP) and diastolic blood pressure (DBP). As a result, 5 SNPs showed statistically significant associations (P＜0.05) with HTN, and 10 SNPs showed statistically significant associations with LVH. rs1002671 and rs9789739 showed significant correlation at the same time with HTN and LVH. These results suggest that the polymorphisms of the SLC8A1 gene are linked to the development of HTN and LVH in Koreans. We expect these results to help us understand the pathogenic mechanisms for HTN and LVH.
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KEYWORD
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Candidate gene analysis, Hypertension, Left ventricular hypertrophy, SLC8A1, SNP
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